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Many herding breeds (most commonly Collies and Australian Shepherds) have a mutation at the MDR1 gene that makes them more sensitive to the negative effects of certain medications. These drugs include several antiparasitic agents (when given at high doses), the antidiarrheal agent loperamide (Imodium®), and several anticancer drugs. The effects of the mutation vary in severity, depending on whether the dog carries one or two copies of the mutation. There is a cheek swab or a commercially-available test that assesses blood samples for the presence of the MDR1 mutation.
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True to his heritage and looks, the Neapolitan Mastiff can be a tough character. He's suspicious of strangers, aloof with acquaintances, but fiercely loyal to family. He's generally laid-back at home, and he doesn't bark a lot. Of course, when he does, you'll hear it.
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Newfoundlands are easygoing, face-washing people lovers and a great choice for the first-time dog owner who is not afraid of a little drool, a big dog, and a lot of hair.
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I will fight him with both paws tied behind my back, I will! Yep, that is a Norfolk all right. Sometimes called a demon in the field, the Norfolk is a terrier through and through, with a feisty, scrappy spirit and plenty of energy for the next great adventure. She may be tiny, but buckle your seatbelts - you are in for a terrier of a good time.
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Cheerful and highly active, Norwegian Buhunds form strong bonds with their families, and they love to snuggle and give kisses. They need plenty of exercise and stimulation, and love to play.
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The Norwegian Elkhound may look threatening, but he can be a sweetie-pie to his people. Threaten those people, however, and this medium-sized, ancient Nordic breed is fully capable of acting as intimidating as he looks.
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Lundehunds are very loving and playful; they form strong bonds, and prefer their own family to any other people. They are also curious and intelligent so they need plenty of engaging toys, and do well at agility training.
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You wanna make something of it? The tiny Norwich Terrier does! This scrappy, feisty, but totally adorable little wire-haired terrier with the prick ears has courage ten times his size. At home, he is all play and mischief, with a great sense of humor and an independent streak that can make training a challenge, but terrier lovers cannot resist his classic terrier attitude.
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The Nova Scotia Duck Tolling Retriever, affectionately called a Toller by her fans, is a recent addition to American Kennel Club activities. A high-energy dog, the are affectionate and outgoing.
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Well-bred Old English Sheepdogs are placid, adaptable individuals who are loving and loyal to their chosen people. These big, lovable dogs can be just the ticket for active households whose members do not mind spending a lot of time tending the tresses of their canine companions.