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If the nerves to the colon do not function normally, the muscles of the colonic wall will not contract properly. The muscles then become stretched and the colon enlarges in diameter. Rather than being pushed into the rectum in a normal manner, fecal material accumulates in the distended colon, resulting in severe constipation called obstipation. This massive enlargement of the colon and the resulting constipation is called megacolon. Megacolon is often treatable using a medical approach but some cases require surgical intervention called subtotal colectomy.
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Megaesophagus is a disorder in which the esophagus dilates and loses motility. When esophageal motility is decreased or absent, food and liquid accumulate in the esophagus and have difficulty getting into the stomach. Regurgitation is the most common sign of megaesophagus. Weight loss or failure to gain weight, as well as aspiration pneumonia, are also common signs. Treatment is focused on managing the symptoms.
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This handout discusses meningitis, an inflammation of the membranes that cover the brain and spinal cord, in cats. The numerous potential causes, along with the diagnosis, treatment and prognosis of the condition are outlined.
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This handout discusses meningitis, an inflammation of the membranes that cover the brain and spinal cord, in dogs. The numerous potential causes, along with the diagnosis, treatment and prognosis of the condition are outlined.
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Meningoencephalitis is a term referring to inflammation of the brain and the surrounding fluid and tissues. Meningoencephalitis of unknown origin is a term used to describe those cases of meningoencephalitis in which MRI and cerebrospinal fluid analysis indicate the disease but diagnosis through histopathological analysis is not possible. Treatment typically involves immunosuppressant drugs, sometimes with the addition of antibiotics. The prognosis depends on several factors, which are also explained in this handout.
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Methylsulfonylmethane is given by mouth and is used over the counter and off label to treat inflammatory conditions such as arthritis. Give as directed by your veterinarian. Side effects are uncommon but may include stomach upset, restlessness, or tiredness. Do not use in pets that are allergic to it or that are pregnant or nursing. If a negative reaction occurs, please call your veterinary office.
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Miconazole topical is an antifungal used in the treatment of skin infections caused by yeast in cats and dogs. It may be used “off-label” or “extra label” for other conditions and in other animals. It may be specially compounded and/or combined into a formulation with other medications. Miconazole topical comes in a variety of forms.
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Feline miliary dermatitis is a skin condition that typically results from an underlying allergic reaction, most commonly to fleabites. An affected cat will have a very itchy rash and may lick, bite, and scratch at the affected skin, quickly progressing to small lesions with scabs on them. The offending allergen must be removed for long-term resolution.
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Mitral valve disease is often one of the earliest indicators of heart disease that could lead to heart failure. It is more common in small dogs than large breeds. This handout discusses mitral valve disease in dogs, a degeneration of the valve between the left atrium and left ventricle. The clinical signs, diagnosis, treatment, and the prognosis of this condition are outlined.
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Many herding breeds (most commonly Collies and Australian Shepherds) have a mutation at the MDR1 gene that makes them more sensitive to the negative effects of certain medications. These drugs include several antiparasitic agents (when given at high doses), the antidiarrheal agent loperamide (Imodium®), and several anticancer drugs. The effects of the mutation vary in severity, depending on whether the dog carries one or two copies of the mutation. There is a cheek swab or a commercially-available test that assesses blood samples for the presence of the MDR1 mutation.
