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  • Diabetes mellitus is an inability to regulate blood glucose caused by a loss of insulin production (Type I) or inadequate insulin supply or resistance (Type II). Dogs need insulin injections to manage diabetes. Sometimes special diets may help manage the disease. Response to insulin needs to be monitored to ensure adequate dosing and to avoid hypoglycemia caused by insulin overdose. Blood glucose curves are most commonly used for this including: in-clinic blood glucose curves, home glucose curves with hand-held glucometers and continuous glucose monitoring systems. Urine glucose testing and fructosamine testing may also be used to manage the disease. Hypoglycemia is the consequence of administering too much insulin compared to the amount of food ingested. Signs can range from lethargy to seizures and coma. It can be managed acutely with administration of sugar syrup to the gums but more severely affected dogs will need IV dextrose solutions.

  • Diabetic ketoacidosis is a medical emergency that occurs when there is not enough insulin in the body to control blood sugar (glucose) levels. It is important for your veterinarian to perform appropriate tests in order to diagnose this disease as similar signs can occur with other medical conditions. Treatment involves hospitalization with IV fluids, short acting insulin and electrolyte replacement. The most important step in prevention is ensuring proper insulin dosing is being administered.

  • The diaphragm is the muscular partition that separates the abdomen and the chest. Tearing or disruption of this thin muscle is called a diaphragmatic hernia or diaphragmatic rupture. The most common cause of diaphragmatic hernia is blunt force trauma. Clinical signs depend on the severity of herniation. There is often respiratory distress, an abnormal heart rhythm, muffled heart and lung sounds, and other signs of systemic shock. The abdomen may feel empty when palpated. Once the patient is stable, the hernia must be corrected surgically.

  • Diarrhea is a symptom of an underlying problem that may be minor or very serious. Some cases may resolve on their own or with minimal treatment, while other cases require in-depth diagnostic testing and more aggressive treatment to address the underlying condition. The possible causes, diagnostic tests, and treatment protocols for diarrhea in dogs are numerous and are explained in this handout.

  • If your dog is having diarrhea, please complete this questionnaire as accurately as possible before your appointment. This information will be very helpful to your veterinarian in determining the cause of diarrhea.

  • Diazepam is given by mouth, injection, or into the rectum and is used off label to treat anxiety, seizures, tense muscles, or decreased appetite. Give as directed by your veterinarian. Side effects include sleepiness, increased appetite, incoordination, weakness, agitation, drooling, and aggression. Do not give to cats by mouth, and do not use in pets that are allergic to it or other benzodiazepines, or in pets with severe liver disease. If a negative reaction occurs, please call your veterinary office.

  • Diazoxide is given by mouth and is used off label to treat low blood sugar associated with insulin-producing tumors of the pancreas. Give as directed by your veterinarian. Common side effects include drooling, lack of appetite, vomiting, and diarrhea. Do not use in pets that are allergic to it or thiazide diuretics, or in pets with low blood sugar due to anything other than a tumor. If a negative reaction occurs, please call your veterinary office.

  • Diclofenac ophthalmic is a topical nonsteroidal anti-inflammatory medication used to treat inflammatory eye conditions in cats, dogs, rabbits, avian species, and other animals. Diclofenac ophthalmic comes in liquid drop form.

  • Diethylstilbestrol is given by mouth and is used off label to treat urinary incontinence. Give as directed by your veterinarian. Side effects are uncommon when using a low dose, but may include mild vaginal spotting. It should not be used in pets that are allergic to it, in females with estrogen-sensitive tumors, in pets with anemia or low white blood cell counts, or in food production animals. If a negative reaction occurs, please call your veterinary office.

  • Difloxacin is given by mouth or as an injection, and is used to treat certain bacterial infections. Side effects are uncommon but may include nausea, vomiting, lack of appetite, and diarrhea. Do not use in pets that are allergic to it, in young or growing animals or in cats. If a negative reaction occurs, please call your veterinary office.

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American Association of Feline Practitioners
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